Zonisamide has beneficial effects
on Parkinson's disease patients
by
Murata M, Horiuchi E, Kanazawa I.
Department of Neurology,
Graduate School of Medicine,
University of Tokyo,
7-3-1 Hongo, Bunkyo-ku,
Tokyo 113-8655, Japan.
mmurata-tky@umin.ac.jp
Neurosci Res 2001 Dec;41(4):397-9

ABSTRACT

Zonisamide (ZNS) is a generally well tolerated anticonvulsant that has beneficial effects on Parkinson's disease (PD). ZNS (300 mg/day) given to a patient with PD who incidentally had convulsive attacks, ameliorated the attacks and, surprisingly, his parkinsonian symptoms. We, therefore, carried out an open trial of ZNS on nine patients with PD. Patients were given 50-200 mg/day ZNS in addition to their anti-PD drugs. Seven clearly showed lessening of symptoms, especially wearing-off. We speculate that long lasting activation of dopamine synthesis by ZNS ameliorates parkinsonian symptoms, in particular wearing-off.

Zonisamide
Bromocriptine
Dopaminergics
Selegiline reviewed
Epilepsy and depression
Mianserin and Parkinson's disease
Selegiline and Parkinson's disease
Apomorphine and Parkinson's disease
Parkinsonian signs/symptoms in depressives

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