Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats
by
Nowak G, Szewczyk B, Wieronska JM, Branski P,
Palucha A, Pilc A, Sadlik K, Piekoszewski W.
Department of Neurobiology, Institute of Pharmacology,
Polish Academy of Sciences, Smetna 12,
PL 31-343, Krakow, Poland
Brain Res Bull 2003 Jul 15;61(2):159-64.

ABSTRACT

The activity of zinc administered intraperitoneally, acutely (in single dose), sub-chronically (in triple doses) or chronically (once daily for 14 days) were assessed in the forced swim test (FST) and olfactory bulbectomy (OB) model of depression in rats. Previously, we have demonstrated that acute administration of zinc sulfate is active in FST in rats and mice. In the present study, zinc hydroaspartate in a dose of 65mg/kg (11.5mgZn/kg), all: acute, sub-chronic and chronic administration, reduced the immobility time in the FST in rats. Removal of olfactory bulbs (OB surgery) in rats is associated with variety of behavioral abnormalities such as deficit in a step-down passive avoidance or hyperactivity in the "open field" test. Both acute and chronic administration of zinc hydroaspartate reduced the number of trials needed to the learning passive avoidance and reduced the OB-induced hyperactivity in rats. At the time schedule following zinc hydroaspartate administration, when behavioral experiments were performed, the serum zinc concentrations were significantly higher than control-physiological values. These results confirm activity of zinc in the FST, show its antidepressant-like activity in the OB rat model of depression, demonstrate the lack of tolerance to these effects and suggest relationship of these antidepressant-like effects with the rise in serum zinc. These animal data further suggest antidepressant activity of zinc in human depression.

Zinc
Folate
Copper
Vitamin E
Dopamine
Chromium
Natural drugs
Food and mood
Slimming drugs
DL-phenylalanine
Vitamins and mood
Docosahexaenoic acid
Mood, food and cognition
The antidepressant onion?
Folate and unipolar depression
Cytokines and major depression
Zinc, the NMDA receptor and depression
BDNF and the antidepressant-like activity of zinc

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family