Antidepressant-like activity of zinc: further behavioral and molecular evidence
by
Sowa-Kucma M, Legutko B, Szewczyk B, Novak K,
Znojek P, Poleszak E, Papp M, Pilc A, Nowak G.
Institute of Pharmacology,
Polish Academy of Sciences,
Smetna 12, 31-343, Kraków, Poland.
J Neural Transm. 2008 Sep 3.
ABSTRACTZinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.Zinc
BDNF
Copper
Vitamin E
Dopamine
Chromium
Natural drugs
Food and mood
Slimming drugs
DL-phenylalanine
Vitamins and mood
Docosahexaenoic acid
Mood, food and cognition
The antidepressant onion?
Folate and unipolar depression
Cytokines and major depression
Zinc, the NMDA receptor and depression
Refs
and further readingHOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
