Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors
by
Shen WW, Urosevich Z, Clayton DO
Saint Louis University School of Medicine,
Missouri, USA.
J Reprod Med 1999 Jun; 44(6):535-42

ABSTRACT

OBJECTIVE: To review the literature describing female orgasmic disorder and impaired sexual desire disorder by selective serotonin reuptake inhibitors (SSRIs) and their treatment, including the use of sildenafil. STUDY DESIGN: Literature reviews of all available published articles on this topic from 1989 to 1996 were done. This paper also includes a sample case of a 38-year old woman who suffers from fluoxetine-induced arousal and orgasmic disturbance. RESULTS: Treatment approaches include the use of "antidotes," such as cyproheptadine, yohimbine, amantadine, granisetron and ginkgo biloba. This article also reports a case of successful female use of sildenafil, which was released by the Food and Drug Administration in March 1998 for erectile dysfunction in men. CONCLUSION: Sildenafil is beneficial in reversing female sexual dysfunction induced by SSRIs. This paper also discusses sildenafil's action in the background of nitric oxide and cyclic guaninosine monophosphate in penile/clitoral erection.

SSRIs
Viagra
Oxytocin
Vardenafil
Yohimbine
Apomorphine
Testosterone
Phentolamine
Coolidge effect
Viagra: review
PT-141 ('Passion')
Viagra: mechanisms
Designer Aphrodisiacs
Viagra: clinical efficacy
Viagra: clinical experience
Disorders of orgasm in women
New sex-drugs: PDE-5 inhibitors
Yohimbine and sexual performance
The pharmacology of penile erection
Drugs to promote female sexual desire
Is sildenafil (Viagra) an antidepressant?
Viagra leaves fake aphrodisiacs flagging
Sidenafil (Viagra) enhances oxytocin release
Sildenafil (Viagra): prescribing information (PDF)

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