Effectiveness and tolerability of tomoxetine in
adults with attention deficit hyperactivity disorder
by
Spencer T, Biederman J, Wilens T, Prince J,
Hatch M, Jones J, Harding M, Faraone SV, Seidman L
Pediatric Psychopharmacology Unit,
Massachusetts General Hospital,
Boston 02114, USA.
Am J Psychiatry 1998 May; 155(5):693-5

ABSTRACT

OBJECTIVE: The authors assessed the experimental noradrenergic compound tomoxetine as an alternative treatment for adult attention deficit hyperactivity disorder (ADHD). METHOD: They conducted a double-blind, placebo-controlled, crossover study of tomoxetine in 22 adults with well-characterized ADHD. RESULTS: Treatment with tomoxetine at an average oral dose of 76 mg/day was well tolerated. Drug-specific improvement in ADHD symptom was highly significant overall and sufficiently robust to be detectable in a parallel-groups comparison restricted to the first 3 weeks of the protocol. Eleven of 21 patients showed improvement after receiving tomoxetine, compared with only two of 21 patients who improved after receiving placebo. Significant tomoxetine-associated improvement was noted on neuropsychological measures of inhibitory capacity from Stroop tests. CONCLUSIONS: This preliminary study showed that tomoxetine was effective in treating adult ADHD and was well tolerated. These promising results provide support for further studies of tomoxetine over an extended period of treatment.

ADHD
Options
Reboxetine
Noradrenaline
Tomoxetine for ADHD
Tomoxetine from Eli Lilly
Once-daily tomoxetine for ADHD
Big Pharma meets Madison Avenue
Antidepressants to treat ADHD in adults
Tomoxetine (Strattera) as an antidepressant
Tomoxetine (Strattera) v methylphenidate (Ritalin)
Atomoxetine (Strattera): prescribing information (PDF)

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family