Structural plasticity and tianeptine:
cellular and molecular targets
by
McEwen BS, Magarinos AM, Reagan LP.
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology,
The Rockefeller University, New York, NY 10021, USA.
mcewen@rockvax.rockefeller.edu
Eur Psychiatry. 2002 Jul;17 Suppl 3:318-30

ABSTRACT

The hippocampal formation, a structure involved in declarative, spatial and contextual memory, undergoes atrophy in depressive illness along with impairment in cognitive function. Animal model studies have shown that the hippocampus is a particularly sensitive and vulnerable brain region that responds to stress and stress hormones. Studies on models of stress and glucocorticoid actions reveal that the hippocampus shows a considerable degree of structural plasticity in the adult brain. Stress suppresses neurogenesis of dentate gyrus granule neurons, and repeated stress causes remodeling of dendrites in the CA3 region, a region that is particularly important in memory processing. Both forms of structural remodeling of the hippocampus are mediated by adrenal steroids working in concert with excitatory amino acids (EAA) and N-methyl-D-aspartate (NMDA) receptors. EAA and NMDA receptors are also involved in neuronal death that is caused in pyramidal neurons by seizures, head trauma, and ischemia, and alterations of calcium homeostasis that accompany age-related cognitive impairment. Tianeptine (tianeptine) is an effective antidepressant that prevents and even reverses the actions of stress and glucocorticoids on dendritic remodeling in an animal model of chronic stress. Multiple neurotransmitter systems contribute to dendritic remodeling, including EAA, serotonin, and gamma-aminobutyric acid (GABA), working synergistically with glucocorticoids. This review summarizes findings on neurochemical targets of adrenal steroid actions that may explain their role in the remodeling process. In studying these actions, we hope to better understand the molecular and cellular targets of action of tianeptine in relation to its role in influencing structural plasticity of the hippocampus.

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Serotonin
Fluoxetine
Tianeptine excess
Tianeptine: review
Tianeptine in India
Tianeptine and stress
Tianeptine compared
Tianeptine: structure
Tianeptine versus paroxetine
Tianeptine as an antidepressant
Tianeptine and alcohol dependence
Tianeptine for asthmatic depressives
Tianeptine, amineptine and dopamine
Tianeptine and stressed out tree shrews

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