Serotonin and norepinephrine transporter binding profile of SSRIs
by
Gutman DA, Owens MJ.
Department of Psychiatry and Behavioral Sciences,
Emory University School of Medicine,
Atlanta, Georgia, USA.
Essent Psychopharmacol. 2006;7(1):35-41.

ABSTRACT

Even today, pharmacotherapy for mood disorders is based almost entirely on the observation in the 1950s and 1960s that agents that enhance monoamine transmitter activity are effective antidepressants. Preclinical studies have shown that long-term administration of nearly all effective antidepressants increases the efficiency of postsynaptic serotonin transmission; many also modify central noradrenergic activity. For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]). Drugs that are highly selective for one transporter over another have been demonstrated to be effective and tolerable, whereas agents that act on multiple transporters may not necessarily achieve better efficacy and may result in additional adverse events. The rationale for the use of drugs that affect multiple transports is based on the suggestion that antidepressants that block both the SERT and the NET may provide better efficacy. This can only be determined through empirical studies.

SSRIs
Risks
Options
Serotonin
Sertraline
Fluoxetine
Paroxetine
Citalopram
Fluvoxamine
SSRIs and sex
SSRIs and PMT
SSRIs and safety
SSRIs and jealousy
SSRI pharmacology
The serotonin receptors
SSRI-induced melancholy
Body dysmorphic disorder
Methylphenidate and SSRIs
Serotonin and romantic lovers
Are SNRIs more effective than SSRIs?
Acute SSRIs and emotional processing
Serotonin and the genetics of depression
Depression, SSRIs and the serotonin 5-HT2 receptors
Are SSRI antidepressants little better than placebos?
Off-label use of selective serotonin reuptake inhibitors (SSRIs)

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