Off-label applications for SSRIs
by
Stone KJ, Viera AJ, Parman CL.
Naval Hospital Jacksonville,
Florida 32214, USA.
Am Fam Physician. 2003 Aug 1;68(3):498-504

ABSTRACT

Selective serotonin reuptake inhibitors (SSRIs) are widely used because of their safety, tolerability, and demonstrated efficacy across a broad range of clinical conditions. Medical literature supports the use of SSRIs for the treatment of many conditions outside of the indications approved by the U.S. Food and Drug Administration. SSRIs offer a reasonable alternative to traditional therapy for generalized anxiety disorder. A side effect of SSRIs coincidentally provides therapy for premature ejaculation. SSRIs may reduce the frequency and severity of migraine headaches and are possibly effective in reducing the pain of diabetic neuropathy. When taken in combination with tricyclic antidepressants, SSRis offer more potent therapy for fibromyalgia than either agent alone. SSRIs appear to be effective in some patients with neurocardiogenic syncope that is refractory to standard therapies. Clinical experience supported by ongoing research continues to expand on the broad array of therapeutic applications for this class of medication.

SSRIs
Risks
Options
Serotonin
Sertraline
Fluoxetine
Paroxetine
Citalopram
Fluvoxamine
SSRIs and sex
SSRIs and PMT
SSRIs and safety
SSRIs and jealousy
SSRI pharmacology
The serotonin receptors
SSRI-induced melancholy
Body dysmorphic disorder
Methylphenidate and SSRIs
SSRIs and depressed children
Serotonin and romantic lovers
PTSD: SSRIs versus Non-SSRIs
Acute SSRIs and emotional processing
Serotonin and the genetics of depression
Are SSRI antidepressants little better than placebos?
OCD and selective serotonin reuptake inhibitors (SSRIs)
Selective serotonin reuptake inhibitors (SSRIs): binding profiles

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