Antidepressant activity of
S-adenosyl-L-methionine in mice and rats
by
Czyrak A, Rogoz Z, Skuza G, Zajaczkowski W, Maj J
Institute of Pharmacology,
Polish Academy of Sciences, Krakow.
J Basic Clin Physiol Pharmacol 1992 Jan-Mar; 3

ABSTRACT

S-Adenosyl-L-methionine (SAM), main methyl donor, was tested in mice and rats in several models which are predictive of possible antidepressant activity. In the forced swimming test in rats the effect of SAM was compared with that of the tricyclic antidepressant amitriptyline. SAM decreased dose-dependently immobility time in the forced swimming test in mice and rats, these effects being antagonized by haloperidol and prazosin (the latter only in rats). Locomotor or exploratory activity in mice and rats was not increased by SAM. D-Amphetamine-induced locomotor hyper-activity in rats was increased by repeated (14 days, twice daily) treatment with SAM. Behavioural stimulation induced by D-amphetamine or L-dopa (given with benserazide) in mice was not changed by a single dose of SAM. The drug reduced hypothermia induced by apomorphine in mice. Hypothermia induced by reserpine or clonidine in mice was not antagonized. SAM increased the amplitude of the acoustic startle reflex. The above results indicate that the psychopharmacological profile of SAM resembles that of antidepressants in only some tests. The mechanism by which SAM produces its antidepressant effect needs further investigation.

Kava
SAMe
NADH
Inositol
Cannabis
Hypericum
SAMe: efficacy
Kava versus valerian
Substance P inhibitors
SAMe as an antidepressant
Nitric oxide synthase inhibitors
SAMe (SAMe): bioavailability and safety
Catechol-O-methyltransferase inhibitors
Methionine, S-adenosyl-l-methionine (SAMe) and the brain
SAMe (S-adenosyl-L-methionine) versus imipramine (Tofranil)


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family