Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats
by
Lelkes Z, Alfoldi P, Erdos A, Benedek G
Department of Physiology,
Albert Szent-Gyorgyi Medical University,
Szeged, Hungary.
Pharmacol Biochem Behav 1998 Aug; 60(4):835-9

ABSTRACT

A study was carried out on the effects on sleep of rolipram, an antidepressant that increases the availability of cAMP by inhibiting a phosphodiesterase isoenzyme. Rats were treated with rolipram (0.1 or 1 mg/kg) twice a day (at light and dark onset) for 11 days, after a chronic period of injection of physiological saline for habituation purposes. The sleep-wake activity was recorded for 12 h following the injection at light onset on the baseline day (physiological saline), on rolipram days 1, 5, and 11, and also on day 12, when physiological saline was injected again (withdrawal day). The high (1 mg/kg) dose of rolipram enhanced wakefulness (W) in postinjection h 1 on day 1 of rolipram treatment. After administration of 0.1 mg/kg rolipram, only a tendency to an increase in W was noted. The promotion of W might be attributed, at least in part, to an increased release of noradrenaline due to a cAMP-mediated stimulation of tyrosine hydroxylase.

Rolipram
Noradrenaline
Rolipram and mood
Rolipram and memory
Tyrosine hydroxylase
Rolipram plus imipramine
Sleep deprivation and mood
Rolipram and new brain cells
Phosphodiesterase inhibitors
Antidepressant rolipram and PDE4D
Rolipram reduces excitotoxic neuronal damage
PDE4D inhibitor rolipram and glucocorticoid receptors
The antidepressant and anti-inflammatory effects of rolipram
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