Fluoxetine targets early progenitor cells in the adult brain
by
Encinas JM, Vaahtokari A, Enikolopov G.
Cold Spring Harbor Laboratory,
Cold Spring Harbor, NY 11724.
Proc Natl Acad Sci U S A. 2006 May 15;

ABSTRACT

Chronic treatment with antidepressants increases neurogenesis in the adult hippocampus. This increase in the production of new neurons may be required for the behavioral effects of antidepressants. However, it is not known which class of cells within the neuronal differentiation cascade is targeted by the drugs. We have generated a reporter mouse line, which allows identification and classification of early neuronal progenitors. It also allows accurate quantitation of changes induced by neurogenic agents in these distinct subclasses of neuronal precursors. We use this line to demonstrate that the selective serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early progenitor cell class. We further demonstrate that these cells are the sole class of neuronal progenitors targeted by fluoxetine in the adult brain and suggest that the fluoxetine-induced increase in new neurons arises as a result of the expansion of this cell class. This finding defines a cellular target for antidepressant drug therapies.

Prozac
Fluoxetine.info
When SSRIs fail
Antidepressants
Partial responders
Fluoxetine and LSD
Fluoxetine and PMT
The David Healy Affair
Fluoxetine and MAO-A
Fluoxetine and MAO-B
Fluoxetine and weight
Fluoxetine and bipolars
Fluoxetine and oxytocin
Fluoxetine : side-effects
Post-E Prozac protection?
Antidepressant mechanisms
Comparisons and metabolites
Fluoxetine (Prozac) : structure
Fluoxetine (Prozac) and 5-HT2c
Fluoxetine and the opioid pathways

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family