Desvenlafaxine succinate for the treatment of major depressive disorder
by
Lohoff FW, Rickels K.
University of Pennsylvania School of Medicine Mood and Anxiety Disorders Section,
Department of Psychiatry, Center for Neurobiology and Behavior,
Translational Research Laboratories, Philadelphia, PA 19104, USA.
lohoff@mail.med.upenn.edu
Expert Opin Pharmacother. 2008 Aug;9(12):2129-36.

ABSTRACT

Major depressive disorder (MDD) remains one of the most common psychiatric disorders with high morbidity and mortality. Effective treatment is limited and response/remission to antidepressant pharmacotherapy remains poor and unpredictable. The development of new antidepressants is thus of great importance to the field. Desvenlafaxine succinate (DVS) is the active metabolite of the serotonin and noradrenaline re-uptake inhibitor venlafaxine and was recently FDA approved for the treatment of MDD. DVS showed efficacy in clinical trials in MDD with doses ranging from 50 - 400 mg. Advantages compared to other antidepressants include once daily dosing at effective doses, no CYP450 metabolism and low drug-drug interactions. Concerns include side effect profile and moderate efficacy. DVS might be a useful addition to the arsenal of antidepressants available to the clinician. Additional studies, in particular head-to-head comparison to other antidepressants and long-term treatment studies, will be necessary to comprehensively evaluate DVS safety and efficacy for clinical practice.

Options
Desvenlafaxine
Venlafaxine v SSRIs
Venlafaxine compared
Venlafaxine v fluoxetine
High-dose venlafaxine XL
Venlafaxine pharmacology
Venlafaxine plus bupropion
Venlafaxine and depression
Venlafaxine and neuropeptides
Venlafaxine and major depression
Venlafaxine for depressive cocaine users
Venlafaxine (Effexor) v clomipramine for OCD
Venlafaxine for treatment-resistant depression
Venlafaxine, emotional processing and the brain
Trial of desvenlafaxine (Pristiq) to treat major depression
Desvenlafaxine (Pristiq) to treat menopausal vasomotor symptoms
February 2008: FDA licenses antidepressant desvenlafaxine (Pristiq)

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family