Personality genetics
by
Benjamin J, Ebstein RP, Belmaker RH.
Laboratory of Clinical Science,
National Institute of Mental Heath, Bethesda, MD, USA.
Isr J Psychiatry Relat Sci 1997;34(4):270-80

ABSTRACT

Although 30-60% of the variance in many personality traits is inherited, until recently little was known about the responsible genes. Preliminary studies of family history in bipolar disorder and of X-linkage of personality traits in color-blindness suggested a "quantitative trait locus" (QTL) approach to the genetics of normal personality. In methodically similar but independent studies of 124 Israeli and 315 American normal volunteers we showed an association between the dopamine D4 receptor gene (D4DR) and the personality trait of novelty seeking. In the Israeli sample we also found an interaction between the D4DR gene and the serotonin 2C receptor gene (5-HT2C) with a marked effect on the trait of reward dependence. Further investigation of genes for personality traits may suggest links between normal personality and psychiatric illness.

D4
D3
D2
D1+D2
Reward
Serotonin 5-HT2c
Dopamine and sex
D4-knockout mice
D3 and antidepressants
Dopamine neurodynamics
Serotonin 5-HT2C receptors
Reward deficiency syndrome
Fluoxetine (Prozac) and 5-HT2c
Dopamine and reward signalling
The genetics of affective disorders
The dopamine D4 receptor gene and personality
Selective 5-HT2C receptor inverse agonists: SB-243213

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