Double-blind comparative study of the action of repeated administration of milnacipran versus placebo on cognitive functions in healthy volunteers
by
Poirier MF, Galinowski A, Amado I, Longevialle R,
Bourdel MC, Tournoux A, Serre C, Loo H.
Service Hospitalo-Universitaire de Sante Mentale et de Therapeutique,
Centre Hospitalier Sainte-Anne, 1 rue Cabanis, 75014 Paris, France.
Hum Psychopharmacol. 2004 Jan;19(1):1-7

ABSTRACT

OBJECTIVE: The principal objective was to compare the effects of milnacipran, an antidepressant characterized by a dual-action on serotonin and noradrenaline reuptake, with placebo on memory, attention and psychomotor performance in healthy volunteers. The secondary objective was to evaluate the effects of milnacipran on mood, anxiety and vigilance in these subjects. METHODS: In a double-blind crossover randomized trial, milnacipran (50 mg b.d.) or placebo was administered during two periods of 7 days separated by a washout period of 7 days. Memory tests (recall of words, images and coloured bars), tests to evaluate attention and vigilance (squares test, critical flicker fusion test and choice reaction time test) and visual analogue scales for affect and sleep were used. RESULTS: There were no significant differences between milnacipran and placebo groups with respect to the psychomotor functions tested. No differences were observed in the Norris scales for vigilance, anxiety or satisfaction or in the sleep questionnaire (sleep latency, sleep quality and waking). CONCLUSION: Milnacipran, administered at 100 mg per day for 7 days to healthy volunteers, had no effects on cognitive functions.

SSRIs
Options
Duloxetine
Nefazodone
Mirtazapine
Venlafaxine
Milnacipran
Antidepressant metabolism
Antidepressant mechanisms
Milnacipran (Ixel) : structure
Milnacipran versus fluvoxamine
Milnacipran and the dopamine system
Milnacipran for post-stroke depression
Milnacipran for depression after brain injury
Milnacipran (Ixel): dosage and antidepressant response
Cabergoline plus milnacipram (Ixel) for refractory depression

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family