Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate
by
Kollins SH, Rush CR, Pazzaglia PJ, Ali JA
Department of Psychiatry and Human Behavior,
University of Mississippi Medical Center, Jackson 39216, USA.
Exp Clin Psychopharmacol 1998 Nov; 6(4):367-74

ABSTRACT

The rate of onset of a drug's effect is an important determinant of its abuse potential. This experiment examined the acute behavioral effects of orally administered sustained-release methylphenidate (SR; 20-40 mg), immediate-release methylphenidate (IR; 20-40 mg), and placebo in 10 healthy volunteers. Drug effects were assessed before drug administration and periodically afterwards for 6 hr using drug-effect questionnaires and performance measures that are sensitive to the acute effects of stimulants. The IR formulation produced stimulant-like drug effects (e.g., increased ratings of "good effects") that generally varied as a function of dose and time. The SR formulation produced only transient effects on these measures. These findings are consistent with previous research on the influence of rate of onset using other drugs and suggest that the abuse potential of IR methylphenidate may be greater than that of SR methylphenidate.

ADHD
SSRIs
Pemoline
Serotonin
Selegiline
Amineptine
Reboxetine
Methylphenidate
Ritalin: long-term effects
Dexmethylphenidate (Focalin)
The rewards of methylphenidate
Methylphenidate versus Adderall
Big Pharma meets Madison Avenue
Methylphenidate (Ritalin) : structure
Methylphenidate, dopamine and cocaine
Psychotic effect of stimulants in a minority of children
Methylphenidate (Concerta): prescribing information (PDF)

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family