A possible mechanism of antidepressant activity of beta-amyrin
palmitate isolated from Lobelia inflata leaves in the forced swimming test
by
Subarnas A, Tadano T, Nakahata N, Arai Y,
Kinemuchi H, Oshima Y, Kisara K, Ohizumi Y.
Pharmaceutical Institute,
Tohoku University, Sendai, Japan.
Life Sci 1993;52(3):289-96
ABSTRACTA mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyrosine (500 mg/kg). Beta-amyrin palmitate (5 and 10 mg/kg) decreased the duration of immobility in mice treated with desipramine plus 6-hydroxy-dopamine (50 micrograms/mouse), but did not affect that induced by nomifensine plus 6-hydroxydopamine. The decreased immobility produced by desipramine (15 mg/kg) was not affected by beta-amyrin palmitate. A study of norepinephrine release in mouse brain synaptosomes indicated that beta-amyrin palmitate caused a release of [3H]norepinephrine. The results of the present study suggest that beta-amyrin palmitate might release norepinephrine from newly synthesized pools, and thus, it might activate noradrenergic activity.Lobelia
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