Acute myo-inositol enhances
swimming activity in goldfish
by
Levine J, Chengappa KN, Reddy R
Stanely Center for the Innovative Treatment of Bipolar Disorder,
Western Psychiatric Institute &
Clinic, Pittsburgh, PA 15213, USA.
J Neural Transm 1999; 106(5-6): 433-41

ABSTRACT

Inositol in concentrations of 1-4 Mm (but not the control condition: mannitol-glucose) administered in aquarium water showed enhancement of swimming activity of goldfish after acute treatment (5 hours). These data support similar findings in rats. These data suggest that inositol may enhance motor activity which may be of relevance in neuropsychiatric disorders. Future studies of the effects of lithium on this activity, and its potential reversal by inositol may shed light on the possible involvement of the phosphatidyl-inositol second messenger system in this behavior.

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