Fluoxetine v. placebo in prevention of relapse
in post-traumatic stress disorder
by
Martenyi F, Brown EB, Zhang H, Koke SC, Prakash A.
Novartis Pharmaceuticals,
Basel, Switzerland.
Br J Psychiatry 2002 Oct;181:315-20

ABSTRACT

BACKGROUND: Little is known about the effect of pharmacotherapy in the prevention of post-traumatic stress disorder (PTSD) relapse. AIMS: To assess the efficacy and tolerability of fluoxetine in preventing PTSD relapse. METHOD: This was a double-blind, randomised, placebo-controlled study. Following 12 weeks of acute treatment, patients who responded were rerandomised and continued in a 24-week relapse prevention phase with fluoxetine (n=69) or placebo (n=62). The primary efficacy assessment was the prevention of PTSD relapse, based on the time to relapse. RESULTS: Patients in the fluoxetine/fluoxetine group were less likely to relapse than patients in the fluoxetine/placebo group (P=0.027). There were no clinically significant differences in treatment-emergent adverse events between treatment groups. CONCLUSIONS: Fluoxetine is effective and well tolerated in the prevention of PTSD relapse for up to 6 months.

PTSD
Fluoxetine.info
Antidepressants
Partial responders
Fluoxetine weekly
Fluoxetine and LSD
Fluoxetine and PMT
Fluoxetine and MAO-A
Fluoxetine and MAO-B
Fluoxetine and weight
Fluoxetine and bipolars
Fluoxetine and oxytocin
Fluoxetine : side-effects
Fluoxetine every third day
Fluoxetine (Prozac) : structure
PTSD: SSRIs versus Non-SSRIs
Fluoxetine and the opioid pathways

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family