Emotional blunting associated with SSRI-induced
sexual dysfunction. Do SSRIs inhibit emotional responses?
by
Opbroek A, Delgado PL, Laukes C, McGahuey C,
Katsanis J, Moreno FA, Manber R.
Int J Neuropsychopharmacol 2002 Jun;5(2):147-51

ABSTRACT

Anecdotal and published case reports suggest that some patients taking selective serotonin reuptake inhibitors (SSRI) experience diminution in emotional responsiveness. This study aims to define the individual components of emotion disturbed in these patients. Fifteen patients reporting SSRI-induced sexual dysfunction completed the Laukes Emotional Intensity Scale (LEIS), a questionnaire about various emotions. Compared to controls, patients reported significantly (p&0.05) less ability to cry, irritation, care about others' feelings, sadness, erotic dreaming, creativity, surprise, anger, expression of their feelings, worry over things or situations, sexual pleasure, and interest in sex. Total score on the LEIS did not correlate with total score on the Hamilton Depression Rating Scale. In our sample, 80% of patients with SSRI-induced sexual dysfunction also describe clinically significant blunting of several emotions. Emotional blunting may be an under-appreciated side-effect of SSRIs that may contribute to treatment non-compliance and/or reduced quality of life.

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SSRIs
5-HT2
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Fluoxetine
Citalopram
Paroxetine
Fluvoxamine
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SSRIs compared
SSRIs: interactions
Escitalopram (Lexapro)
Serotonin control genes
Antidepressant mechanisms
Pleasure, decision and desire
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Antidepressant drugs and emotion
Dapoxetine v paroxetine to treat PE
Premature ejaculation and serotonin
Drugs to treat premature ejaculation
Are SSRI antidepressants little better than placebos?
Selective serotonin reuptake inhibitors reduce emotional lability

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