Functional involvement of cerebral diazepam binding inhibitor (DBI) in the establishment of drug dependence
by
Katsura M.
Department of Pharmacology,
Kawasaki Medical School,
Kurashiki 701-0192, Japan.
mkatsura@med.kawasaki-m.ac.jp
Nippon Yakurigaku Zasshi 2001 Mar;117(3):159-68

ABSTRACT

Mechanisms for formation of drug dependence and emergence of withdrawal syndrome are not yet fully understood despite of a huge accumulation of experimental and clinical data. Several clinical features of withdrawal syndrome are considered to be common (i.e., anxiety) among patients with drug dependence induced by different drugs of abuse. In this review, we have discussed the possibility of the functional involvement of diazepam binding inhibitor (DBI), an endogenous neuropeptide for benzodiazepine receptors with endogenously anxiogenic potential, in the development of drug dependence and emergence of its withdrawal symptom. The levels of DBI protein and its mRNA significantly increased in the brain derived from mice dependent on alcohol (ethanol), nicotine and morphine, and abrupt cessation of these drugs facilitated further increase in DBI expression. In the cases of nicotine- and morphine-dependent mice, concomitant administration of antagonists for nicotinic acetylcholine and opioid receptors, respectively, abolished the increase in DBI expression. Therefore, these alterations in DBI expression have a close relationship with formation of drug dependence and/or emergence of withdrawal syndrome and are considered to be a common biochemical process in drug dependence induced by different drugs of abuse.

GABA(A)
Diazepam
Sedatives
Triazolam
Adinazolam
Temazepam
Clonazepam
Valium advert
Diazepam: structure
Benzodiazepine abuse
Benzodiazepines ligands
Benzodiazepine dependence
Diazepam (Valium) and the potato: the natural origin of benzodiazepines

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family