Dopamine D2, D3 and D4 receptor and transporter
gene polymorphisms and mood disorders
by
Manki H, Kanba S, Muramatsu T, Higuchi S,
Suzuki E, Matsushita S, Ono Y, Chiba H,
Shintani F, Nakamura M, Yagi G, Asai M
Department of Neuropsychiatry,
Keio University School of Medicine,
Tokyo, Japan.
J Affect Disord 1996 Sep 9; 40(1-2):7-13
ABSTRACTDisturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.D4
D3
D2
D1
D1+D2
Reward
Deliriants
Dopamine
Neuroleptics
Dopamine and sex
D4-knockout mice
D3 and antidepressants
Dopamine neurodynamics
Reward deficiency syndrome
Dopamine deficiency and depression
Depression, dopamine and dextroamphetamine
Mesolimbic medium spiny neurons and pleasure
Regulation of synapses in the nucleus accumbens
The nucleus accumbens: opioids versus cannabinoids
Refs
and further readingHOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
