A Randomized, Double-blind, Placebo-controlled Study of Citalopram in Adolescents With Major Depressive Disorder
by
von Knorring AL, Olsson GI, Thomsen PH, Lemming OM, Hulten A.
*Department of Neuroscience, Child and Adolescent Psychiatry,
University Hospital, SE-75185 Uppsala, Sweden;
Psychiatric Hospital for Children and Adolescents,
University Hospital of Aarhus,
Harald Selmers Risskov, Denmark;
Department of Biostatistics, H. Lundbeck, Valby, Denmark;
Department of Suicide Research and Prevention,
Karolinska Institute, Stockholm, Sweden.
J Clin Psychopharmacol. 2006 Jun;26(3):311-315.

ABSTRACT

ABSTRACT:: In a European, multicenter, double-blind study, 244 adolescents, 13 to 18 years old, with major depression were randomized to treatment with citalopram (n = 124) or placebo (n = 120). One third of the patients in both groups withdrew from the study. No significant differences in improvement of scores from baseline to week 12 between citalopram and placebo were found. The response rate was 59% to 61% in both groups according to the Schedule for Affective Disorders and Schizophrenia for school-aged children-Present episode version (Kiddie-SADS-P) (depression and anhedonia scores /=50% reduction). Remission (MADRS score

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