Prophylactic effect of citalopram in unipolar, recurrent depression: Placebo-controlled study of maintenance therapy
by
Hochstrasser B, Isaksen PM, Koponen H, Lauritzen L,
Mahnert FA, Rouillon F, Wade AG, Andersen M,
Pedersen SF, Swart JC, Nil R.
Privatklinik, Meiringen, Switzerland.
Br J Psychiatry 2001 Apr; 178(4):304-10

ABSTRACT

BACKGROUND: Major depression is highly recurrent. Antidepressant maintenance treatment has proven efficacy against recurrent depression. AIMS: Comparison of prophylactic efficacy of citalopram versus placebo in unipolar, recurrent depression. METHODS: Patients 18-65 years of age with recurrent unipolar major depression (DSM-IV), a Montgomery-f1.gif" BORDER="0">sberg Depression Rating Scale score of >/=22 and two or more previous depressive episodes, one within the past 5 years, were treated openly with citalopram (20-60 mg) for 6-9 weeks and, if responding, continued for 16 weeks before being randomised to double-blind maintenance treatment with citalopram or placebo for 48-77 weeks. RESULTS: A total of 427 patients entered acute treatment and 269 were randomised to double-blind treatment. Time to recurrence was longer in patients taking citalopram than in patients taking placebo (P:<0.001). Prophylactic treatment was well tolerated. CONCLUSIONS: Citalopram (20, 40 and 60 mg) is effective in the prevention of depressive recurrences. Patients at risk should continue maintenance treatment at the dose necessary to resolve symptoms in the acute treatment phase.

OCD
SSRIs
Serotonin
Dopamine
Escitalopram
Clomipramine
Sertraline and OCD
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Citalopram and OCD
Alcohol and citalopram
Citalopram and ecstasy
SSRIs and panic disorder
Citalopram and selegiline
Citalopram v amitriptyline
Citalopram and depression
Citalopram and panic disorder
Serotonin and romantic lovers
Citalopram and eating disorders
Citalopram: oral versus intravenous
Citalopram (Cipramil, Celexa) plus methylphenidate (Ritalin)

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