Open trial of bupropion SR in adolescent major depression
by
Glod CA, Lynch A, Flynn E, Berkowitz C, Baldessarini RJ.
Bouve College of Health Sciences,
Northeastern University, Boston, MA, USA.
DrGlod@aol.com
J Child Adolesc Psychiatr Nurs. 2003 Jul-Sep;16(3):123-30

ABSTRACT

PROBLEM: There are few studies of sustained-release bupropion in adolescents with major depression. METHODS: Twenty-one adolescents with DSM-IV major depression were recruited through advertisement and self-referral; 11 began study medication and were rated weekly with an expanded Hamilton Depression Rating Scale (SIGH-SAD), as well as Clinical Global Impression-Improvement (CGI-I). RESULTS: Of 11 subjects enrolled, 8 completed an 8-week trial of bupropion SR. Mean baseline SIGH-SAD scores of 31.3 decreased significantly by 74% to mean endpoint score of 8.2. Improvement on CGI-I that agreed closely between raters and patients was found in 8 of 11 subjects (72.3%). The mean daily dose of bupropion SR was 362 mg +/- 52 mg and was well tolerated; insomnia and weight loss were experienced by 55%; other adverse effects of dry mouth, headache, agitation, light-headedness, diarrhea, or rash were noted in a minority of subjects. CONCLUSIONS: In this preliminary, small open study, depressed adolescents showed a marked response to bupropion SR.

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