Antidepressant-induced hepatotoxicity
by
Lucena MI, Carvajal A, Andrade RJ, Velasco A.
Instituto de Farmacoepidemiologia
de la Universidad de Valladolid, Spain.
Expert Opin Drug Saf. 2003 May;2(3):249-62.

ABSTRACT

Depression is a chronic, severe and increasingly prevalent illness associated with substantial morbidity, mortality and healthcare costs. Antidepressant drugs, the cornerstone of depression treatment, are not devoid of adverse effects, including hepatotoxicity. To review the risk of liver toxicity related to major antidepressants, the authors have followed structural criteria focusing on the underlying mechanism presumably involved and the role of particular chemical structures. The clinicopathological expression goes from transient increases in liver enzymes to fulminant liver failure. Classical antidepressants such as monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants (TCAs) seem to have the highest potential to induce liver damage compared with the newer drugs such as selective serotonin re-uptake inhibitors (SSRIs). The potential for severe hepatotoxicity associated with nefazodone is stressed. Guidelines for therapy and prevention of antidepressant-induced hepatotoxicity are also discussed.

TCAs
SSRIs
Options
Nefazodone and PTSD
Nefazodone in pregnancy
Nefazodone: legal challenge
Nefazodone and social phobia
Nefazodone pharmacokinetics
Nefazodone versus imipramine
Nefazodone (Serzone) : structure
Nefazodone and/or psychotherapy
Nefazodone for pathological gamblers

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family