Antidepressant-like activity of amisulpride
in two animal models of depression
by
Papp M, Wieronska J
Institute of Pharmacology,
Polish Academy of Sciences,
Krakow.
nfpapp@cyf-kr.edu.pl
J Psychopharmacol (Oxf) 2000 Mar;14(1):46-52

ABSTRACT

Clinical reports suggest that amisulpride, in addition to its antipsychotic efficacy, may also have antidepressant properties. The present study was designed to evaluate potential antidepressant-like activity of amisulpride in two behavioural procedures: the forced swim test (FST) and the chronic mild stress (CMS) model. The duration of immobility time in FST was reduced by subchronic (three injections over a 24 h period) administration of imipramine (10 mg/kg) and amisulpride (1 and 3 mg/kg), although the effect of imipramine was more potent. The 5 mg/kg dose of amisulpride was marginally effective and higher doses of 10 and 30 mg/kg were inactive. In CMS, the stress-induced decrease in the consumption of 1% sucrose solution was gradually reversed by chronic treatment with imipramine (10 mg/kg) and amisulpride (5 and 10 mg/kg). Lower (1 or 3 mg/kg) or higher (30 mg/kg) doses of amisulpride were inactive. The magnitude of the effect of active doses of amisulpride in the CMS model was comparable to that of imipramine but its onset of action was faster; at the most active dose of 10 mg/kg, amisulpride significantly increased the sucrose intake in stressed animals within 2 weeks of treatment while imipramine required 4 weeks before first effects on the stress-induced deficit in sucrose consumption could be observed. These results provide further support for clinical observations that amisulpride may posses potent and rapid antidepressant activity.

Options
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Amisulpride and the dopamine D2 and D3 receptors
The dopaminergic deficit: amisulpride and mood disorders
Does serotonin 5-HT(7a) receptor antagonism underlie antidepressant effect of low-dose amisulpride (Solian)?

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