Alprazolam-induced hypomania
by
Reddy J, Khanna S, Anand U, Banerjee A
Department of Psychiatry,
National Institute of Mental Health and Neurosciences,
br> Actas Esp Psiquiatr 1999 May-Jun; 27(3):191-7

ABSTRACT

OOBJECTIVE: There are reports of alprazolam-induced hypomania/mania. Here is a case report of a patient who developed hypomania during treatment with alprazolam, but not with diazepam, another benzodiazepine derivative. CLINICAL PICTURE: The illness was of 2 months' duration and the patient received a diagnosis of anxious depression. Following treatment with alprazolam, the patient developed hypomania characterised by euphoria, overactivity, overtalkactivity, racing thoughts, oversocialisation, enhanced self-confidence and disturbed sleep. TREATMENT: Hypomania subsided when alprazolam was withdrawn. There was no recurrence with fluoxetine or diazepam that ameliorated the primary condition. OUTCOME: The patient was symptom-free on follow-up. CONCLUSIONS: Alprazolam can induce hypomania/mania and, perhaps, it differs from other benzodiazepines in its mode of action. Clinicians have to be alert to the possibility of their patients developing hypomania/mania while on alprazolam.

Xanax
Anxiety
Valerian
Gepirone
Buspirone
Zopliclone
Adinazolam
Beta-blockers
Alprazolam SR
GABAergic drugs
Benzodiazepines
Future anxiolytics
Drug-induced mania
Low-dose alprazolam
Long-term alprazolam
Alprazolam : structure
Anxiolytics/antidepressants
Alprazolam and panic disorder

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