Increased anxiety of mice
lacking the serotonin1A receptor
by
Parks CL, Robinson PS, Sibille E, Shenk T, Toth M.
Howard Hughes Medical Institute,
Department of Molecular Biology,
Princeton University, Princeton, NJ 08544-1014, USA.
Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10734-9
ABSTRACTBrain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.5-HT2
5-HT3
5-HT1a
5-HT1b
5-HT1d
5-HT2a
5-HT2c
F11440
MKC-242
Buspirone
Mirtzapine
Flibanserin
Eltoprazine
Aggression
Knockout mice
5-HT2c/5-HT2b
5-HT1a v 5-HT1b
MDMA and 5-HT1a
Suicide and 5-HT1a
5-HT1a and F11440
5-HT1a and anxiety
A rheostat in the brain for emotion?
5-HT1a agonists as antidepressantsand further reading
Refs
HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
