Comparison of sublingual and oral
prazepam in normal subjects. I. Clinical data
by
Ansseau M, von Frenckell R, Jacqmin P.
Department of Neuropsychiatry,
Centre Hospitalier Universitaire,
Liege Sart Tilman, Belgium
Neuropsychobiology 1987;18(2):77-82

ABSTRACT

Five normal volunteers received at a 2-week interval a single dose of sublingual or oral prazepam in double-blind and cross-over conditions. All subjects completed a battery of 15 visual analogue scales before drug intake and 7.5, 15, 22.5, 30, 45, 60, 90 min, 2, 3, 5, 6, 7, 8, 9, 10 and 24 h following intake whereas a computerized assessment of vigilance (reaction time) was performed before intake, 15, 30, 60 min, 2, 3, 6, 8, 10 h following intake. Subjects rated themselves significantly more feeble, clumsy, lethargic, and incompetent following sublingual as compared to oral prazepam while a trend in the same direction was noted for the adjectives muzzy and mentally slow. In contrast, reaction time did not exhibit significantly different changes over time between the two forms. These results suggest a subjectively more rapid onset of activity following sublingual compared to oral prazepam.

DBI
GABA(A)
Sedatives
Triazolam
Adinazolam
Temazepam
Clonazepam
Benzodiazepine abuse
Prazepam v diazepam
Prazepam v lorazepam

Refs
and further reading

HOME
HedWeb
Cocaine.org
Future Opioids
BLTC Research
Nootropics.com
Superhappiness?
Utopian Surgery?
The Abolitionist Project
MDMA: Utopian Pharmacology
Critique Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family