Premenstrual dysphoric disorders: a diversified
cluster of vulnerability traits to depression
by
Halbreich U
Department of Psychiatry,
State University of New York at Buffalo 14215, USA.
Acta Psychiatr Scand 1997 Mar; 95(3):169-76

ABSTRACT

Some biological factors which have been shown to be abnormal in subgroups of women with dysphoric premenstrual syndromes (PMS) have not been limited to the symptomatic late luteal phase of the menstrual cycle, but also existed during the non-symptomatic mid-follicular phase of the cycle. Personality, cognitive functions, alpha 2 and imidazoline binding, sensitivity to inducement of panic attacks, relative hypothyroidism, and some but not all serotonergic functions of women with dysphoric PMS differ from those with no PMS, and also differ during a non-symptomatic phase of the cycle. It is suggested that premenstrual symptoms are an expression of vulnerability traits that might surface in response to a trigger. Such traits are probably diverse, and the nature of the symptoms might depend upon the underlying trait. It is postulated-that some vulnerability traits to specific premenstrual syndromes might also be vulnerability traits to depression or anxiety in general.

SSRIs
Estrogen
Fluoxetine
Magnesium
Imidazoline
SSRIs and PMT
Sertraline and PMT
Fluoxetine and PMT
Tryptophan and PMT
Calcium, PMT and mood
Alpha2 adrenoreceptors
Antidepressants and breast milk

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