Melatonin and cortisol "switches" during mania, depression, and euthymia in a drug-free bipolar patient
by
Kennedy SH, Tighe S, McVey G, Brown GM
Department of Psychiatry,
University of Toronto,
Ontario, Canada.
Am J Psychiatry 1998 Aug; 155(8):1119-21

ABSTRACT

Low melatonin and elevated cortisol levels have typically been reported during depression. The evidence that the converse is true during mania has been less well documented. In a single case design, repeated measures of nocturnal melatonin and cortisol were taken during mania, depression, and euthymia. Elevated levels of melatonin during mania and elevated cortisol levels during depression were the principal findings. There also did not appear to be any marked change in circadian rhythm of hormone output during the three clinical states. The implications of these findings in relation to noradrenergic dysfunction are discussed.

Options
Serotonin
Melatonin
Tryptophan
Light therapy
Noradrenaline
Bipolar disorders
Winter depression
Melatonin ligands

Refs
HOME
HedWeb
Future Opioids
BLTC Research
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best To Take Crack Cocaine?

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family