Gabapentin leads to remission of somatoform
pain disorder with major depression
by
Maurer I, Volz HP, Sauer H
Department of Psychiatry,
Friedrich-Schiller-Universitat Jena,
Germany.
maurer@landgraf.med.uni-jena.de
Pharmacopsychiatry 1999 Nov;32(6):255-7

ABSTRACT

Gabapentin, a novel antiepileptic drug, is effective in the treatment of partial seizures with and without secondary generalization. Evidence suggests that it may have mood-stabilizing and possibly antidepressant properties in bipolar depression. We report on a 48-year-old woman who had recurrent major depressive disorder. Following inguinal herniorrhaphy, she developed severe stabbing pain in the lower abdomen and inguinal area that progressed to constant pain in her whole body. She was depressive, hopeless, and had given up her social activities. A diagnosis of major depressive disorder and somatoform pain disorder was made. Antidepressants and carbamazepine were ineffective, and she had attempted suicide. Gabapentin resulted in remission of both the pain and the depressive mood at a dose of 1.800 mg/day.

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