Changes in weight during a 1-year trial of fluoxetine
by
Michelson D, Amsterdam JD, Quitkin FM, Reimherr FW,
Rosenbaum JF, Zajecka J, Sundell KL, Kim Y, Beasley CM Jr
Lilly Research Laboratories,
Eli Lilly and Company,
Indianapolis, IN 46285, USA.
dmichelson@lilly.com
Am J Psychiatry 1999 Aug; 156(8):1170-6


ABSTRACT

OBJECTIVE: Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported. Weights were assessed for patients whose depressive symptoms had disappeared with acute fluoxetine treatment. Patients were then randomly assigned to continuation treatment with fluoxetine or placebo. METHOD: Patients whose illness had remitted after 12 weeks of treatment with fluoxetine, 20 mg/day, were randomly assigned to receive up to 38 weeks of treatment with fluoxetine or placebo. Weight was assessed at each visit. Change in weight was analyzed during the initial 12 weeks of acute treatment and after 14, 26, and 38 weeks. Relationships between weight change and body mass index and between weight change and appetite change were assessed. RESULTS: During the initial 4 weeks of therapy, a mean absolute weight decrease of 0.4 kg was observed for all patients. Among patients who completed 50 weeks of therapy, the mean absolute weight increase during continuation treatment was similar for both the placebo- and fluoxetine-treated groups. Weight increase was not related to initial body mass index but was related to both poor appetite at study entry and to improvement in appetite after recovery. No patients discontinued therapy because of weight gain. CONCLUSIONS: Acute therapy with fluoxetine is associated with modest weight loss. After remission of depressive symptoms, weight gain for patients taking fluoxetine for longer periods is not different from that for patients taking placebo and is most likely related to recovery from depression.

SSRIs
Dosage
Fluoxetine
Sibutramine
SSRIs and sex
Slimming drugs
Prozac for tiny tots?
Fluoxetine and MAO-B
Fluoxetine and cocaine
Fluoxetine and oxytocin
Fluoxetine and dopamine
Fluoxetine: 10th Anniversary
Antidepressants and bulimia nervosa
Fluoxetine: norepinephrine, dopamine and 5-HT2c
Fluoxetine (Prozac): prescribing information (PDF)
Fluoxetine: dosage and outcome in antidepressant trials
Body weight changes associated with psychopharmacology


Refs
and further reading

HOME
HedWeb
Nootropics
Cocaine.org
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family