Treatment of depression
by
Payk TR
Westfalisches Zentrum fur
Psychiatrie der Ruhr-Universitat,
Bochum, Germany.
J Geriatr Psychiatry Neurol 1994 Oct; 7 Suppl 1:S3-5

ABSTRACT

Depressions are the most common psychiatric diseases. For treatment, plant extracts have been used for thousands of years: examples are extracts from the (sleeping) poppy (opium), deadly nightshade (Atropa belladonna), Indian hemp (hashish), henbane (hyoscyamine), thorn apple (scopolamine), and St. John's wort (hypericum oil). In addition, psychotherapeutic measures, like playing music, dancing, playing theatre, and also the temple sleep, were used. In the 19th century, the introduction of brome (1826), codeine (1832), chloral hydrate (1869), and paraldehyde (1882), as well as the barbiturates (at the turn of the century) introduced significant improvements in pharmacotherapy. The modern thymoleptica therapy started in 1957 with the introduction of imipramine. Now about 40 active antidepressants are marketed. New drug developments should be characterized mainly by an improvement in tolerance.

TCAs
SSRIs
Options
Reward
Cocaine
Cannabis
Recovery
Dopamine
Barbiturates
St John's wort
Chronic depression
Atypical depression
Retarded depression
New antidepressants
Antidepressants: how fast?
Antidepressants and the brain

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