Bromocriptine and imipramine in endogenous depression. A double-blind
controlled trial in out-patients
by
Waehrens J, Gerlach J
J Affect Disord 1981 Jun; 3(2):193-202
ABSTRACT
Among 33 out-patients with endogenous depression, 16 were treated with
bromocriptine (10-60 mg/day, mean 34) and 17 with imipramine (75-250 mg/day,
mean 143). The total score on the Hamilton Rating Scale decreased during 6-week
treatment from 19.9 to 7.8 in the bromocriptine group (P less than 0.001) and
from 20.1 to 6.1 in the imipramine group (P less than 0.001). There was no
significant difference between the two groups. The main side-effects were for
bromocriptine: nausea, dizziness, and headache; for imipramine; dryness of
mouth, dizziness, and sweating. This study suggests an antidepressant effect of
bromocriptine although, due to the possibility of Type II error, it may not
necessarily be equal to that of imipramine.
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