Neuropharmacologic treatment of bronchial asthma with the antidepressant
tianeptine: a double-blind, crossover placebo-controlled study
by
Lechin F, van der Dijs B, Orozco B,
Jara H, Rada I, Lechin ME, Lechin
AE
Section of Psychopharmacology,
Institute of Experimental Medicine,
Central
University of Venezuela, Caracas.
flechin@telcel.net.ve
Clin Pharmacol Ther 1998 Aug; 64(2):223-32
ABSTRACT
Studies have shown the levels of free serotonin in plasma are increased in
symptomatic patients with asthma. In addition, the concentration of free
serotonin in symptomatic children with asthma correlates positively with
clinical status and negatively with pulmonary function (forced expiratory volume
in 1 second [FEV1]). Thus, reducing the concentration of free serotonin in
plasma may be useful in treating children with asthma. We studied the
effectiveness of tianeptine in treating these patients. Tianeptine is the only
drug known to be able to reduce the level of free serotonin in plasma and to
enhance the uptake by platelets. Sixty-nine of the 82 children with asthma
initially enrolled participated in this study. Children were randomized to
receive tianeptine or placebo or both in a double-blind crossover trial. The
trial lasted 52 weeks. Tianeptine provoked a dramatic and sudden decrease of
both clinical rating and free serotonin plasma levels and an increase in
pulmonary function.
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